National Neurological AIDS Bank

What Is The Purpose Of The NNAB Study?

The National Neurological AIDS Bank (NNAB), is a longitudinal study of persons with advanced AIDS and other serious diseases. It was first established to better understand how HIV-1 causes neurological disease and gain insight on commorbid conditions. The NNAB was created to respond to researchers, who need well characterized human tissue and fluid samples. The NNAB recruits volunteer subjects with AIDS and HIV-negative subjects with other diseases (such as cancer and ALS) to participate in our longitudinal study. All volunteers agree to donate their tissues and organs at death. The NNAB collaborates with scientists all over the world who are studying neurological diseases, and supplies them with valuable samples. Our participants include men and women, age 18 and older of a variety of ethnicities, racial backgrounds and socioeconomic groups. Complete examinations are conducted in both English and Spanish and participants are compensated for their time.

Want to Join the NNAB?

The NNAB is always looking to recruit new participants in our studies. Participants are compensated for each visit and can be provided transportation to and from study locations as needed. Individuals who are interested in participating in our research studies should call: 310-206-1151 and ask for the Study Coordinator.

More about The NNAB Study

The NNAB is a longitudinal study of well-characterized subjects with advanced AIDS and HIV-seronegative (HIV-) subjects, who have agreed to have serial neurological and neuropsychological examinations during their life, and to donate blood, urine and cerebrospinal fluid (CSF) during life and their organs and tissues after their death. NNAB collects these tissues and organs and distributes them to qualified investigators for research into the pathogenesis of Neuro-AIDS. NNAB characterizes its cohort using standardized NNTC protocols in Neuromedicine, Neuropsychology, Psychiatry/Substance Abuse, and Neuropathology, to achieve consensus diagnoses that are monitored by the NNTC Quality Assurance Committees. In addition, NNAB independently collects information that is essential to study the association between co-morbid medical conditions, such as Hepatitis C virus (HCV) infection, hypertension, diabetes, lipid disorders, as well as the adverse effects of retroviral therapy and HIV neurological disease. The NNAB cohort is unique because of its diversity, and reflects the gender, ethnic, and racial distribution of AIDS in Los Angeles. NNAB has stimulated the development of independently funded projects studying CSF viral load, HCV and the nervous system, and magnetic resonance spectroscopy (MRS) as a tool for following HIV neurological disease. These projects and the information they generate further enrich the value of our tissue collection. NNAB provides an increasingly important resource that mirrors the changing face of the AIDS epidemic and is capable of adapting as the needs of investigators dictate.